Chemiluminescent probes for imaging H2S in living animals

Chemiluminescent probes for imaging H2S in living animals† †Electronic supplementary information (ESI) available: Detailed experimental procedures, characterization of compounds, computational methods, optimized geometries, atomic charges, supplementary figures, and replicate images. See DOI: 10.1039/c4sc03516j Click here for additional data file.

Hydrogen sulphide (H2S) is an endogenous mediator of human health and disease, but precise measurement in living cells and animals remains a considerable challenge. We report the total chemical synthesis and characterization of three 1,2-dioxetane chemiluminescent reaction-based H2S probes, CHS-1, CHS-2, and CHS-3. Upon treatment with H2S at physiological pH, these probes display instantaneous ...

Photoacoustic probes for real-time tracking of endogenous H2S in living mice.

H2S is a key chemical mediator that exerts a vital role in diverse physiological and pathological processes. However, in vivo tracking of endogenous H2S generation still remains difficult due to the lack of reliable analytical methods. Herein, we present the first example of activatable photoacoustic probes for real-time imaging of H2S in living mice through the full utilization of the superior...

Photoacoustic probes for real-time tracking of endogenous H2S in living mice† †Electronic supplementary information (ESI) available: Procedures for the synthesis of BODPA, living mice imaging, characterization data, and supplementary figures. See DOI: 10.1039/c6sc04703c Click here for additional data file.

A Redox-Nucleophilic Dual-Reactable Probe for Highly Selective and Sensitive Detection of H2S: Synthesis, Spectra and Bioimaging

Hydrogen sulfide (H2S) is an important signalling molecule with multiple biological functions. The reported H2S fluorescent probes are majorly based on redox or nucleophilic reactions. The combination usage of both redox and nucleophilic reactions could improve the probe's selectivity, sensitivity and stability. Herein we report a new dual-reactable probe with yellow turn-on fluorescence for H2...

Fluorescent Probes and Selective Inhibitors for Biological Studies of Hydrogen Sulfide- and Polysulfide-Mediated Signaling

SIGNIFICANCE Hydrogen sulfide (H2S) plays roles in many physiological processes, including relaxation of vascular smooth muscles, mediation of neurotransmission, inhibition of insulin signaling, and regulation of inflammation. Also, hydropersulfide (R-S-SH) and polysulfide (-S-Sn-S-) have recently been identified as reactive sulfur species (RSS) that regulate the bioactivities of multiple prote...